Projects ERC-MINING and PNRR-COMBO

Projects:

ERC MINING

Capturing the dynamics of brain activity in its multifaceted components is a key challenge for neural interfaces, deciphering the complex electrical and chemical signaling exchanged by the different constituents of the brain tissue.

MINING aspires at generating a novel class of multifunctional neural endoscopes, able to trigger and detect electrical and molecular signaling with cellular resolution in vivo in a brain volume. The result will be the unprecedented ability to correlate multiple types of signals in the same volume, with spatial and temporal resolution at depth. The limitation of current state of the art will be surmounted by exploiting light-matter interactions in hybrid metal-dielectric metasurfaces and their synergistic integration with organic electrochemical transistors.

PNRR COMBO proposes a technology for multifunctional monitoring of brain-on-chip (BOC) systems at high spatio-temporal resolution. Bioprinting and organ-on-chip technologies will be synergistically integrated, devising novel approaches to host advanced optical systems for fiber-based vibrational spectroscopy, volumetric functional imaging and electrophysiological recordings. This entails the utilization of tapered optical fibers, proficient in extracting molecular information through Raman spectroscopy.